Endometriosis
Endometriosis isn’t one disease — it’s many.
Diversity in immune responses, hormone receptor expression, and transcriptomic profiles all suggest that endometriosis manifests uniquely in each individual, requiring personalized diagnostic and therapeutic approaches.
One Size Does Not Fit All
Understanding Endometriosis
The Lotus Endometriosis Institute takes a unique stance on endometriosis that you are unlikely to find elsewhere. Recent molecular and genomic research strongly supports the notion that endometriosis is not a single disease entity, but a heterogeneous condition composed of distinct subtypes. Each of these subtypes have potentially different origins, clinical behavior, and treatment responses. Some of it is genetic, some of it you can influence, and some you cannot.
What is it?
Endometriosis is a condition where cells similar to the uterine lining (endometrium) grow outside the uterus, potentially into the pelvis or abdomen. The condition has varying severities and symptoms.
When can it happen?
Endometriosis can occur at any age. It can be found in your teens, early childhood, or even earlier in-utero as a fetus. The condition primarily affects middle aged women, but can also be post-menopausal.
Why does it occur?
The exact causes are not currently known, and they likely differ from person to person. Contributors possibly include embryologic müllerianosis, genetics & epigenetics, molecular translational changes, pelvic tissue transformation called metaplasia and more. It is most definitely "multi-factorial" and "polygenic".
Where can it spread?
Endometriosis can affect not only your pelvic organs and delicate structures, which include your bladder, ureters and rectum, but also outside your pelvis higher up in the abdomen. There it can involve your intestines. Endometriosis can spread literally anywhere in your body, including the lungs (metastatic) and beyond.
Common Issues
Symptoms
Endometriosis often presents with symptoms that can vary greatly in severity and impact, making it challenging to recognize early. While some people experience debilitating pain, others may have subtle signs that are easily overlooked or mistaken for common menstrual issues. Understanding the range of potential symptoms is the first step toward earlier diagnosis and effective treatment.
Pelvic / Abdominal Pain
Persistent or cyclical pain in the pelvis and lower abdomen is one of the most common symptoms, often worsening around menstruation but not limited to it.
Bloating
Abdominal bloating, sometimes called “endo belly,” can appear suddenly, feel severe, and fluctuate day to day.
Painful Sex
Discomfort or sharp pain during or after intercourse is common, often tied to inflammation, scarring, or adhesions.
Infertility
Endometriosis can interfere with fertility by affecting the ovaries, fallopian tubes, or pelvic environment, though many with the condition do conceive with treatment.
Urinary Frequency
Some experience urgency or frequent urination, particularly if lesions involve the bladder.
Painful Bowel Movements
Bowel movements may trigger cramping or sharp pain, especially during menstrual cycles.
Back and Leg Pain
Pain can radiate into the lower back, hips, or legs, reflecting how endometriosis affects surrounding nerves and tissues.
And Far More
Symptoms extend well beyond this list, with wide-ranging effects on the body and quality of life—making awareness and individualized evaluation essential.
Because Your Experience Matters
Every symptom tells a story—we are here to listen to yours.
We understand how overwhelming and isolating these symptoms can feel, and you don’t have to face them alone. At Lotus Endometriosis Institute, we combine world-class surgical expertise with integrative, whole-person care to uncover the true root of your pain. This unique approach gives you the best chance at lasting relief, restored health, and a better quality of life. Take the first step toward healing—reach out today and let us help guide you forward.
Different for Everyone
Subtypes & Stages
The ASRM (American Society for Reproductive Medicine), defines four stages of endometriosis. The stages are not necessarily proportional to pain or symptoms. Some patients exhibit less pain than others, even if they have a higher stage diagnosis. Additionally, the condition can be described by different "subtypes" including: superficial endometriosis (on peritoneal surface), deep infiltrating endometriosis (invading tissues), ovarian endometriomas ("chocolate cysts"), metastatic endometriosis (spread to distant areas), and malignant degeneration (rare but life-threatening).
Stage 1 - Minimal
There are small patches or implants either on or around the organs in the pelvis.
Stage 2 - Mild
Increasing number of implants but damage to the pelvic organs is still minimal with not much scarring or adhesions. Altogether, the implants are not more than ~5cm.
Stage 3 - Moderate
Implants are more widespread and are beginning to infiltrate the organs in the pelvic region, including pelvic side walls, ureters, and peritoneum. There is more scarring and adhesions and endometriomas (“chocolate cyts”) on the ovary.
Stage 4 - Severe
The disease is infiltrating and affecting several organs (e.g. bladder, rectum) in the pelvic region, as well as the ovaries. Anatomy is severely distorted with scars and adhesions, with fibrosis (like concrete) between organs. Larger and more endometriomas can be seen.
Insights for Your Health
Prevention and Detection
While the near future may bring molecular genetic insights into targeted prevention, today there is no reliable way to prevent endometriosis. In fact, there is a genetic predisposition which is not well understood. If you have a relative with endometriosis, you have a 5-7x risk of being affected. What those genetic switches are will be uncovered soon and prevention and treatment will be enhanced. Meanwhile, you can do a lot towards reducing the chances it will affect you and maybe decrease endometriosis progression. We provide integrative insights into endometriosis-reducing lifestyle-modifications, and they are as natural a strategy for endometriosis treatment as it gets.
Excision Surgery Leads the Way
Surgical Treatment
Surgery plays a central role in endometriosis care, serving as both a diagnostic tool and today’s gold-standard for initial treatment of pain relief, infertility, and suspicious masses. Because endometriosis can vary depending on where it is located—inside or outside the pelvis—and what stage it has reached, treatment must be carefully tailored to each individual. Minimally invasive excision surgery offers accurate diagnosis while providing effective symptom relief, but it should be strategically timed, as repeated procedures can increase scar tissue and risk. For the best outcomes, the benefits must always outweigh the risks, making timing and the expertise of the surgeon essential to every decision.
Common Questions
How is recurrent endometriosis diagnosed after excision?
Recurrent endometriosis after excision is diagnosed by combining your symptom pattern with expert evaluation—not by symptoms alone. We start by taking a detailed history of what’s changed since surgery (timing, cyclicity, location, and triggers like bowel movements, bladder filling, sex, or ovulation) and comparing it to your “new baseline” after healing. A careful exam can reveal clues such as focal tenderness, pelvic floor dysfunction, or signs that another condition is overlapping with—or mimicking—endo.
Imaging can be very helpful when interpreted with endometriosis expertise, especially ultrasound or MRI to look for issues like recurrent endometriomas, deep disease, adenomyosis, pelvic masses, or other pelvic conditions that can drive similar symptoms. At the same time, it’s important to know imaging doesn’t catch every form of endometriosis, and lesion size doesn’t always match symptom severity. When persistent or returning pain doesn’t fit a clear recurrence pattern, we often widen the lens to evaluate “look-alikes” and coexisting drivers—such as pelvic venous congestion, hernias, nerve-related pain, central sensitization, or gut and immune factors—so treatment is targeted rather than guesswork.
Because surgery remains the only definitive way to confirm endometriosis, confirmation of true disease recurrence may ultimately require repeat surgery and pathology in selected cases—but that decision should be individualized and based on a structured workup. If you’re worried about recurrence, our team can help you map your symptoms, choose the right testing, and build a long-term plan focused on durability and reassurance.
Can scar tissue look like endometriosis on ultrasound or MRI?
Yes. Scar tissue (adhesions or postoperative scarring) can sometimes resemble endometriosis on imaging, and endometriosis itself can also create fibrosis that looks “scar-like.” Ultrasound and MRI can be very helpful when they’re expertly performed and interpreted, but the findings can still land in a gray zone—especially when inflammation, prior surgery, or distorted anatomy is involved.
This is also why we don’t diagnose (or rule out) endometriosis based on imaging alone. Our approach is to pair imaging with your full symptom story, flare pattern, and exam findings, and to actively consider look-alike or coexisting conditions (like adenomyosis, pelvic floor dysfunction, hernias, or vascular causes) that can mimic endometriosis pain.
When the distinction truly matters for your treatment plan, the most definitive answer usually comes from surgery with histopathology of excised tissue. If you’ve been told imaging “looks like endo” (or “just scar tissue”) but your symptoms don’t add up, reach out—our team can help you sort out what’s most likely and what next steps make sense.
Can endometriosis be confirmed by biopsy without surgery?
In most cases, a biopsy that confirms endometriosis requires a procedure to actually reach and sample the suspected lesion—so “biopsy without surgery” is usually not possible for typical pelvic endometriosis. Endometriosis is confirmed when a pathologist sees endometrial-type glands and stroma (sometimes with bleeding-related changes) in the tissue sample, but the challenge is obtaining the right tissue from the right spot.
Even during surgery, biopsy results can be negative if the sample misses a tiny focus of disease, if endometriosis is hiding beneath a normal-looking surface, or if it’s located deeper (for example within bowel wall) where superficial sampling won’t capture it. That’s why visual appearance alone can be misleading, and why surgeon experience and sampling technique matter.
If you’re trying to avoid surgery, our team can still build a strong working diagnosis using your symptom pattern, exam, and expertly interpreted imaging, while also looking for conditions that mimic or amplify endometriosis pain. When you’re ready, we can walk you through when surgical evaluation with excision and pathology is most helpful—and how we use the tissue information to tailor longer-term planning.
What are endometriosis red flags in teens?
Endometriosis can start in the teen years, and one of the biggest red flags is period pain that’s more than “normal cramps”—pain that’s severe, escalating over time, or keeps returning month after month. Missing school, sports, or social plans because of periods (or needing stronger pain meds that still don’t touch the pain) is another common warning sign. Pelvic pain that isn’t limited to bleeding days—mid‑cycle pain, daily pelvic aching, or flares with activity—can also fit the pattern.
Other red flags include bowel or bladder symptoms that track with the menstrual cycle, such as painful bowel movements, diarrhea/constipation flares, painful urination, or pelvic pressure during periods. Pain with tampon use or pelvic exams, and pain with sexual activity in older teens, can also be clues. If these patterns sound familiar, our team can help you sort out what’s most likely driving the symptoms (including endometriosis and common “look‑alikes”), review any prior records or imaging, and map out clear next steps toward a real diagnosis and durable relief.
How is endometriosis diagnosed in teenagers?
Diagnosing endometriosis in teenagers starts with taking symptoms seriously and getting the full story—when pain began, whether it’s cyclical or constant, what triggers flares, and how it affects school, sports, sleep, mood, and daily life. Our team looks for patterns that fit endometriosis (and adenomyosis) while also screening for common “look-alikes” or overlapping issues that can mimic or amplify pelvic pain, like pelvic floor dysfunction, GI conditions, or hormonal and inflammatory contributors.
Imaging such as ultrasound or MRI can sometimes identify suspected endometriosis or related conditions (like ovarian endometriomas), but normal imaging does not rule endometriosis out—especially in adolescents. The only way to confirm endometriosis with certainty is through minimally invasive surgery (laparoscopy) with biopsy, and in some cases excision of visible disease at the same time. If you’re a teen (or a parent of one) trying to get clear answers, we can review symptoms and prior records, explain what testing is most useful, and help you understand when a surgical diagnosis may—or may not—be the right next step.
Can IVF workup detect endometriosis?
Yes—endometriosis can be suspected during an IVF workup, but it’s often not definitively “found” unless there’s a clear clue. Antral follicle count ultrasound may reveal an ovarian endometrioma, and your history (painful periods, pain with sex, bowel/bladder symptoms, prior cysts) can raise suspicion even when routine imaging looks normal.
What IVF testing typically can’t do is reliably rule endometriosis out. Superficial disease and many forms of deep endometriosis may be missed on standard pelvic ultrasound, and even high-quality imaging needs expert interpretation to identify subtler patterns or related conditions like adenomyosis.
If endometriosis is a concern during fertility planning, our team focuses on a thorough, story-driven evaluation plus targeted exam and expertly interpreted ultrasound/MRI when appropriate—so you’re not left guessing between “unexplained infertility” and a potentially treatable root cause. If you’re in the middle of IVF decisions, reach out to schedule a consultation so we can help you clarify what may be present and how it could impact next steps.

