Which genes are linked to endometriosis so far?

Genome-wide association studies suggest endometriosis risk is influenced by many common genetic variants, each with a small effect, rather than one single “endometriosis gene.” Signals have been found near genes including WNT4, GREB1, ESR1, FSHB, VEZT, FN1, SYNE1, and IL1A.

Taken together, these findings point to biology involved in hormone signaling and progesterone response, uterine lining changes (decidualization), inflammation/immune activity, and tissue remodeling outside the uterus. Genetics can help explain why endometriosis tends to run in families, but it doesn’t currently replace a clinical evaluation or guide treatment on its own—if you’re concerned about inherited risk or persistent symptoms, our team can help you sort through the next best steps.