Explore the latest evidence on endometriosis—from who is affected and why, to genetic insights and emerging therapies—so you can understand risks, advances, and what promising treatments may mean for you.
Research in endometriosis is moving fast, uncovering why disease starts, why it persists, and which treatments truly help. Summaries here translate high‑quality studies on prevalence, risk factors, pain mechanisms, immune and hormonal signaling, fibrosis, and comorbidities into clear, practical takeaways. Expect context on strengths and limits of study designs, from population cohorts to surgical registries and randomized trials, so it’s easier to judge what findings mean for daily life and shared decision‑making.
Because endometriosis is heterogeneous and often overlaps with adenomyosis, we highlight how results may differ by phenotype and life stage, and when insights extend to adenomyosis with links to Adenomyosis. For deeper dives into specific streams, explore Epidemiology, Genetics, Biomarkers, and New Treatments, or see how innovations in tests relate to care in Diagnostics & Imaging. Learn what’s promising, what’s proven, and how to talk with your clinician about trial options and timing relative to surgery, fertility plans, and symptom goals.
Multiple blood, urine, saliva, and menstrual‑fluid biomarker panels show promise, but none yet meet accuracy standards to replace laparoscopy or expert imaging. Today, diagnosis relies on symptoms assessed alongside targeted ultrasound or MRI; biomarkers may soon complement, not replace, these tools. Track developments in Biomarkers and their clinical use in Diagnostics & Imaging.
Beyond hormones, trials are testing non‑hormonal approaches that target inflammation, nerve sensitization, angiogenesis, and fibrosis, as well as microbiome‑informed strategies. Early results are encouraging for some drug classes, but most remain experimental and should be used only in trials or specialist‑guided care. For up‑to‑date pipelines and readiness levels, see New Treatments.
A well‑designed trial can provide access to emerging therapies and contribute to better care, but it may involve randomization, extra visits, or placebo. Discuss eligibility, safety monitoring, and how participation aligns with planned surgery, fertility timelines, and current medications. Search ClinicalTrials.gov and ask your endometriosis specialist about local options.
Endometriosis varies widely by lesion type, location, and prior treatment, and many studies include small, highly selected groups. Differences in diagnostic methods, outcome definitions, and follow‑up length also drive conflicting results. Looking for replication across larger, diverse cohorts and randomized trials helps distinguish signal from noise.
Microbiome studies show associations with inflammation and hormone metabolism, but clinical trials proving that specific probiotics or diets reliably reduce disease activity are still limited. Nutrition can support symptom control and overall health, but it should complement—not replace—medical care. For practical, evidence‑informed strategies, see Gut Health and Nutrition, and supplement guidance in Supplements.
We break down an 18‑month follow‑up of hormone therapy for adenomyosis: who was studied, symptom trends, ultrasound changes, side effects, and key limitations.
2025 meta-analysis of relugolix for endometriosis: pain relief, QoL gains, side effects and add-back therapy, plus comparison with leuprorelin.
HBOT for endometriosis: how hyperbaric oxygen may work, what the evidence shows, when to consider it as adjunct care, plus safety and contraindications.
How epigenetic mechanisms and DNA methylation shape endometriosis, how your diet may modulate them, and the implications on your endometriosis care.
Explore how immune dysfunction may link endometriosis to autoimmune diseases such as lupus, RA, thyroid disease, celiac, MS, and IBD - evidence and care.
Understand how endometriosis affects ovarian, breast, thyroid, and cervical cancer risk, plus symptoms to watch, screening guidance, and ways to lower risk.
Explore the link between lupus (SLE) and endometriosis: outcomes, key results, clinical implications, and priorities for future research.
Learn about postmenopausal endometriosis: who is at risk, diagnosis and treatment basics, and why malignant transformation is rare but worth knowing.
Learn how genetics shapes endometriosis—familial clustering, gene mapping, GWAS, and genomics—and what this means for diagnosis, treatment, and monitoring.
Explore how the microbiome may shape inflammation and estrogen metabolism in endometriosis, and what emerging research means for diagnosis and new therapies.
How endometriosis may be linked to earlier menopause: key evidence, contributing factors, care implications, and practical coping strategies.
How endometriosis and inflammatory bowel disease differ and overlap. Symptoms, diagnostic challenges, epidemiology, treatment risks, and research gaps.
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