What is the estrobolome, and why does it matter for endometriosis?

The estrobolome is the group of gut microbes involved in how your body processes estrogen. Some of these microbes produce enzymes (including beta-glucuronidase) that can convert estrogen into forms that are more likely to be reabsorbed instead of eliminated. In simple terms, your gut can influence how much estrogen circulates in your body over time.

This matters in endometriosis and adenomyosis because these conditions are often estrogen-responsive, and shifts in estrogen metabolism can affect symptoms for some patients. Constipation and gut microbiome imbalance can contribute to estrogen recirculation, which may intensify bloating, pelvic pain, or cycle-related flares. If you’re noticing a strong link between digestive changes and symptom severity, our team can help you sort out the full picture and discuss next-step options as part of your evaluation.