AMH Or Follicle Count Which Matters More For Endometriomas

When you’re worried about fertility, numbers can feel like destiny

If you have an ovarian endometrioma (“chocolate cyst”), you’ve probably been offered ovarian reserve testing—most commonly a blood test called AMH (Anti Mullerian Hormone) and an ultrasound count called AFC (antral follicle count). It can be scary to see a low number and wonder: “Is my time running out? Did the cyst damage my ovary? Should I rush into surgery or IVF?”

Here’s the tricky part: with endometriomas, different tests may tell slightly different stories. Recent evidence suggests that AFC (what’s happening in each ovary on ultrasound) may capture the “local” impact of an endometrioma more clearly than AMH does—especially when the cyst is on one side or when cyst size varies.

This matters because the goal isn’t just collecting results. The goal is using the right information to choose the next step that best protects your quality of life and your reproductive options.

What are AMH and AFC in plain language?

AMH (Anti-Müllerian Hormone) is a blood test that roughly reflects how many small follicles you have across both ovaries combined. It’s convenient and commonly used in fertility planning and IVF.

AFC (Antral Follicle Count) is an ultrasound-based count of small resting follicles (usually 2–10 mm) seen in each ovary. It can be more “granular,” because it shows what’s happening ovary-by-ovary, not just the overall picture.

In real life, clinicians often use both, because each has strengths and blind spots—especially in endometriosis.

If your endometrioma is on one side, the affected ovary may look “lower reserve” on ultrasound

One of the most immediately relevant findings for patients: when women had a unilateral (one-sided) endometrioma, the ovary with the cyst had a lower AFC than the other, “healthy” ovary.

What this can mean for you:

• • If your ultrasound report says the ovary with the endometrioma has fewer follicles, you’re not imagining things—and you’re not alone.
  • It also means a single AMH number may not reflect the imbalance between ovaries. You could have one ovary doing relatively well while the other is being affected.

This can be especially important if you’re deciding between monitoring vs surgery, or planning IVF—because stimulation outcomes can depend on how each ovary responds.

Bilateral endometriomas may reduce total follicle count even when AMH looks similar

If you have endometriomas on both ovaries, you may be more likely to see lower AFC counts overall compared with having only one-sided disease. But in this dataset, AMH did not clearly differ between unilateral and bilateral groups.

What this can mean in practice:

• • If you have bilateral cysts and your AMH looks “okay,” it may still be worth asking: “What is my total AFC and what is the AFC per ovary?”
  • If AFC is low but AMH isn’t dramatically low, you deserve a careful, individualized interpretation—not dismissal. Sometimes the “average” (AMH) can hide meaningful side-to-side changes (AFC).

Cyst size may matter for AFC, even if AMH doesn’t change much

Another patient-relevant takeaway: larger cyst diameter was linked with lower AFC in the corresponding ovary. Meanwhile, AMH was not correlated with cyst size in the same way.

Why you should care:

• • If your endometrioma is growing, the ultrasound follicle count in that ovary may trend down as size increases.
  • If your AMH stays relatively stable, you might still be experiencing a “local” effect that AMH isn’t sensitive enough to reflect—especially if your other ovary is compensating.

This doesn’t prove the cyst causes the decline (this kind of research can’t fully prove cause and effect), but it supports a very practical point: tracking cyst size and AFC over time may give you more actionable information than AMH alone.

AMH and AFC usually move together—just not perfectly

In this dataset, AMH and AFC were positively correlated, and the relationship between AMH and total AFC was moderate (not perfect).

Your real-world takeaway:

• • If AMH and AFC match (both reassuring or both low), decisions may feel clearer.
  • If they don’t match (for example, AMH is okay but AFC is low on the affected side), that mismatch is a reason to slow down and interpret results carefully with someone experienced in endometriosis and fertility.

So… should you trust AFC more than AMH if you have an endometrioma?

If your main question is, “How is this cyst affecting this ovary?”—AFC may be more informative, because it can detect side-specific differences and appears more linked to cyst size.

If your main question is, “What is my overall ovarian reserve picture right now?”—AMH is still useful, especially when combined with AFC, age, symptoms, and your goals.

A helpful way to think about it:

• • AFC = local map (per ovary)
  • AMH = overall weather report (whole system)

Many patients benefit from using both—then making decisions based on the full picture, not a single number.

Practical takeaways for your next appointment

Bring your goals (pain control? pregnancy soon? preserving options?) and use your test results to get clear on next steps. Consider asking:

• • “Can you tell me my AFC in each ovary, not just total?” If one ovary is doing most of the work, that changes planning.
  • “Has my endometrioma size changed, and how does that relate to my AFC?” If size is increasing and AFC is falling on that side, you may want a time-sensitive plan.
  • “Given my numbers and symptoms, should we monitor, use medical suppression, consider egg freezing/IVF, or consider surgery—and in what order?”
  • “If surgery is on the table, what is your plan to minimize ovarian tissue loss, and how might this affect my AFC/AMH afterward?” (This is crucial with endometriomas.)
  • “How does recurrence history affect my risk of declining reserve or needing repeat treatment?” In this dataset, recurrence history was the only factor linked with AMH in multivariable analysis—worth discussing even though it’s not definitive.

Reality check: what this does not mean

It’s understandable to read “lower AFC in the affected ovary” and feel panic. But a few grounding points matter:

First, correlation isn’t destiny. This type of evidence can’t prove that cyst growth directly causes follicle loss in every person. It tells you what tends to travel together in real patients.

Second, AMH isn’t “useless” in endometriosis—it’s just not always sensitive to what’s happening on one side or to cyst size.

Third, low reserve markers don’t automatically mean you can’t get pregnant, and they don’t measure egg quality perfectly. They mainly help predict how you might respond to ovarian stimulation and how urgently you may want to preserve fertility options.

Finally, your best plan depends on your full context: pain severity, age, cyst growth pattern, prior surgeries, fertility timeline, and whether you have access to an endometriosis-experienced surgeon and/or fertility specialist.