Skip to main content
Lotus Endometriosis Institute solid color logo
A beautiful landscape of lotus flowers

Does a Longer Endometriosis Surgery Mean More Complications? What a 2025 Study Found.

What a 2025 study reveals about operative time, complications, and recovery in stage III–IV minimally invasive endometriosis surgery.

By Dr Steven Vasilev
POV of a female surgeon arranging laparoscopic instruments beside a running digital timer in a clean, modern OR prep area.

Hearing that your minimally invasive surgery for advanced (stage III–IV) endometriosis may take “a long time” can be stressful. Many patients understandably worry that a longer operation automatically means a higher risk of complications.


A 2025 study in BMC Women’s Health looked directly at this question in people undergoing minimally invasive surgery for pathology-confirmed stage III–IV endometriosis at a high-volume, specialized U.S. center—and offers some reassuring, practical insights.


Why surgery can take longer in stage III–IV endometriosis


Advanced endometriosis can involve significant pelvic scarring and distortion and may require more complex surgical steps. The study notes that stages III and IV represent advanced disease and may require complex, sometimes multi-organ procedures. In real life, that complexity often translates into longer operating times.


Study snapshot (what was studied, and where)

  • Study type: Retrospective cohort study
  • Who: Patients aged 18–51 with pathology-confirmed stage III–IV endometriosis
  • What: Minimally invasive surgical treatment for endometriosis
  • Where: A high-volume tertiary care center in the U.S.
  • When: Surgeries from Nov 1, 2013 to Oct 31, 2023
  • Main question: Is longer operative time linked to short-term postoperative complications?
  • Secondary question: Is longer operative time linked to overnight hospital admission?


Important note: The provided materials do not include detailed definitions of “short-term,” specific complication types, or the exact operative-time cutoffs beyond percentile thresholds and “each additional 60 minutes.” When information isn’t available, it’s safest not to guess.


Key findings: Operative time and short-term complications


1) Longer surgery time was not linked to more short-term postoperative complications


The study’s primary finding was that longer operative times were not associated with increased short-term postoperative complications in minimally invasive surgery for stage III–IV endometriosis. This held true across multiple operative-time thresholds (including the 50th and 90th percentiles) and when looking at additional time in 60-minute increments.


What this may mean for you: If your surgeon says your procedure may take longer due to complexity, this study suggests that—in a specialized, high-volume setting—a longer time in the operating room does not automatically translate into a higher risk of short-term postoperative complications.


2) Intraoperative complications were higher at one threshold—but postoperative complications were not


At the 50th percentile threshold, the study observed a higher rate of intraoperative complications among longer surgeries. However, postoperative complication rates did not significantly differ across operative-time groups (including higher thresholds like the 75th and 90th percentiles).


How to interpret this carefully: This finding does not mean longer surgery is “risk-free.” It means that in this dataset, longer time wasn’t a clear driver of postoperative complications—even though there was a signal for intraoperative issues at one threshold.


A clear takeaway: Longer surgery increased the chance of an overnight stay


While complications weren’t higher, overnight admission was. The study found operative time was a consistent predictor of needing to stay overnight:

    • Each additional hour of surgery increased the odds of overnight admission by 64% (adjusted odds ratio 1.64; 95% CI 1.30–2.06).


What this may mean for you: If your surgeon anticipates a long case, it may be wise to plan emotionally and logistically for the possibility that you won’t go home the same day—even if everything goes smoothly.


Worried about surgery time?

Our specialists are here to help you understand your condition and explore your treatment options.

Schedule Your Exam

Why “thoroughness over speed” matters in complex endometriosis surgery


The authors emphasize a clinical priority that many endometriosis patients value: doing the surgery carefully and comprehensively, even if it takes longer. In advanced disease, rushing can be risky, and meticulous technique may be more important than a shorter operative time.


What to ask your surgeon (actionable checklist)


Because this study was done at a specialized center, it’s especially helpful to discuss how your own setting compares. Consider asking:


Experience and setting

    • “Do you/your team specialize in stage III–IV endometriosis surgery?” This is the most important question because anyone or any "team" can do a lot of relatively easy cases. That does not usually predict safety or success for complex anatomically distorted cases.
    • “Is this a high-volume center for complex endometriosis cases?” This has to be tightly tied to the first question. In many centers doing multiple easy cases per day is valued way too much and this does not make the surgeon an expert. So, "high volume" needs to be taken in context if comparing to others. For example, it would be almost impossible for a surgeon to perform 300 4-6 hour surgeries in any given year. But for easy multiple cases per day, it becomes feasible.

What a longer operative time means for my plan

    • “If my surgery runs long, how does that change my recovery plan?”
    • “What would make you recommend an overnight stay?”

Expectations and safety

    • “How do you monitor and manage complications during and after surgery?”
    • “What support services are available if my case is complex (multidisciplinary support)?”

Outcomes beyond the short term

    • This study did not assess long-term outcomes such as pain recurrence or fertility. You can ask:
    • “How will we track long-term symptom relief and other goals after surgery?”


Important cautions (how not to overapply these results)


This study includes some key limitations that matter for patients:

    • Setting matters: The findings came from a quaternary referral center where surgeries were performed mostly by highly experienced endometriosis specialists, and results may not generalize to lower-volume centers or less specialized teams.
    • Long-term outcomes weren’t studied: The research did not evaluate long-term issues such as chronic pain recurrence, fertility, or late complications, which could potentially be influenced by operative time.
    • Don’t assume longer is “better”: The authors caution against misreading the results as proof that longer surgeries reduce complications. The overall complication rate was relatively low, which may limit the ability to detect small risk differences.


Bottom line for patients


For minimally invasive surgery for stage III–IV endometriosis performed at a specialized, high-volume center, this study found that a longer operative time was not associated with more short-term postoperative complications. However, longer surgery did increase the likelihood of an overnight hospital admission, so planning ahead is wise.


If you’re facing surgery, the most helpful next step is often not focusing on the clock—but on the experience of your surgical team, the resources of the center, and a clear recovery plan tailored to your case.


Quick Answers

What are signs endometriosis has returned after surgery?

Endometriosis “returning” after surgery can show up as symptoms that improve for a while and then gradually (or suddenly) come back months or even years later. The most common signal is the return of your familiar pattern—cyclical pelvic pain, worsening period pain, pain with intercourse, or pain that starts spreading beyond where it used to be. Some people also notice bowel or bladder symptoms re-emerge (pain with bowel movements, rectal pressure, urinary urgency or bladder pain), especially if those organs were involved before. New or increasing fatigue and activity limitation can be part of the picture, but the key is a clear change from your post-op baseline.


It’s also important to know that recurrent pain doesn’t always equal recurrent disease. Even after complete excision, the nervous system can stay “turned up,” and pelvic floor dysfunction, adhesions, or central sensitization can keep pain going or make normal sensations feel painful—so we think in terms of patterns, triggers, and timing rather than a single pain score. If symptoms are returning, our team can help you sort whether you’re in a true recurrence lane (improved, then returned) versus persistent pain that never fully settled, and decide when imaging (such as ultrasound or MRI) is useful—particularly for tracking ovarian endometriomas. If you’re noticing a shift back toward your old symptoms, reach out to schedule a consultation so we can build a clear, long-term follow-up plan with you.

Read full answer

What questions should I ask an endometriosis specialist?

Come in focused on how your surgeon thinks and how your care will be mapped out. Helpful questions include: based on my symptoms and records, what diagnoses are you considering (endometriosis, adenomyosis, and common look‑alikes), and what makes you lean one way or another? Ask what additional records or imaging would meaningfully change the plan, and whether your imaging will be interpreted with endometriosis mapping in mind—not just a “normal/abnormal” read.


If surgery is on the table, ask for specifics about technique and scope: do you primarily perform excision (rather than superficial burning/ablation), and how do you confirm what was removed (photos, operative report detail, pathology)? Ask what areas you expect could be involved in your case (ovaries, bowel, bladder/ureters, diaphragm) and whether a multidisciplinary team is planned if those organs may be affected. It’s also reasonable to ask how they define surgical “success” for your goals—pain relief, bowel/bladder function, fertility—and how outcomes and recurrence/persistent symptoms are handled.


Finally, ask how the care process works from start to finish: what the pre‑op workup includes, what recovery typically looks like for the anticipated complexity, and how follow‑up is structured if symptoms don’t resolve fully. In our practice, we review records purposefully before meeting so the conversation is productive and realistic, and we’ll be direct about whether surgery seems likely to help or whether another path makes more sense. If you’d like, you can reach out to schedule a consultation and we’ll tell you exactly what to send first so we can make your visit worth your time.

Read full answer

Is endometriosis surgery only for fertility?

No—endometriosis surgery is not only for fertility. Excision surgery is often performed primarily to relieve pain and other symptoms, to restore normal anatomy when disease has scarred or “frozen” the pelvis, and to address endometriosis affecting organs like the bowel, bladder, ureters, or diaphragm. Surgery can also be the most definitive way to confirm the diagnosis, because endometriosis isn’t always visible on imaging.


Fertility can be an important goal, but it’s just one possible indication—and it’s not always the reason to operate. For example, removing an ovarian endometrioma before IVF is no longer considered “routine” unless there’s a clear reason such as severe pain, concerning imaging features, or a practical barrier to safe egg retrieval. In our practice, we focus on tailoring excision to what problem we’re trying to solve in your body—symptom relief, organ safety/function, diagnosis, fertility goals, or a combination—so you can make a decision that fits your timeline and priorities. If you’re unsure whether surgery makes sense in your situation, you can reach out to schedule a consultation with our team to review your symptoms, imaging, and goals and map out an individualized plan.

Read full answer

Can I get endometriosis treatment if I’m not trying to get pregnant?

Yes. Endometriosis care is not “fertility-only” care—treatment is appropriate whether your goal is pregnancy, pain relief, protecting organs, improving daily function, or simply getting clear answers. We routinely treat patients who are not trying to conceive, because endometriosis can drive ongoing inflammation, adhesions, and symptoms that affect quality of life regardless of fertility plans.


A good plan separates two goals that often get mixed together: treating the disease itself and managing symptoms. Symptom-focused options (including hormonal suppression and individualized pain management strategies) can reduce pain and bleeding for many people, but they don’t reliably remove endometriosis lesions. When endometriosis is confirmed and symptoms or organ involvement warrant it, excision surgery is the cornerstone approach to physically remove disease—then we tailor longer-term support based on your symptoms, risks, and preferences.


If you’re not trying to get pregnant, that can actually expand your options for symptom control—but it doesn’t change the importance of an accurate diagnosis and a plan that matches what’s driving your symptoms. If you’d like, reach out to schedule a consultation so our team can review your history, imaging, and goals and map out a strategy focused on lasting relief—not just temporary suppression.

Read full answer

How soon can endometriosis come back after surgery?

Endometriosis can recur as early as a few months after surgery, but for many patients it’s more likely to show up over years rather than weeks. The timing varies because “recurrence” can mean different things—new or returning symptoms, a lesion seen on imaging, or a cyst such as an ovarian endometrioma coming back.


What most often determines how soon it returns is whether any disease was left behind (including microscopic or visually hidden implants), along with factors like disease severity, where it was located, whether endometriomas were involved, and whether adenomyosis is also present. It’s also important to know that pain can flare even when lesions were thoroughly removed, because the nervous system and pelvic floor can stay sensitized after years of inflammation.


Our approach is to treat surgery as a major turning point—not the finish line—by focusing on complete excision and a clear long-term plan for follow-up and symptom tracking. If you’re noticing symptoms returning after surgery (or you’re planning surgery and want to understand your recurrence risk), reach out to schedule a consultation so our team can review your history and tailor a strategy for durable relief.

Read full answer

Reach Out

Have a question?

Dr. Steven Vasilev delivers best-in-class endometriosis guidance and a personalized treatment plan—built on evidence and your unique biology.


Led by Steven Vasilev, MD—an internationally recognized endometriosis specialist & MIGS surgeon—Lotus Endometriosis Institute is virtual-forward, with many patients traveling nationally for care. Clinical evaluation and surgical treatment are provided in California.

Santa Monica, CA

2121 Santa Monica Blvd, Santa Monica, CA 90404

Operating Hours

8:00 am - 5:00 pm
Monday - Friday

Arroyo Grande, CA

154 Traffic Way, Arroyo Grande, CA 93420